Brostallicin had predictable and predominantly hematologic toxicities. Activity was demonstrated in a number of solid tumor types. A phase II study of brostallicin in relapsed/refractory soft tissue sarcoma had sufficient activity based …
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Many of these aberrations have emerged as prognostic and predictive markers in hematologic cancers and certain types of solid tumors. Furthermore, the molecular characterization of cytogenetic abnormalities has provided insights into …
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Gram-positive bacteremia was found to be catheter-related in 55% and 69% of patients with hematologic malignancy and solid tumors, respectively, whereas gram-negative bacteremia was catheter-related in only 19% of patients with …
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Chronic lymphocytic leukemia (CLL) and acute myelogenous leukemia (AML) are the two most common types of leukemia diagnosed in adults nationwide, and non-Hodgkin lymphoma (NHL) is the most common hematologic cancer nationwide. …
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This review gives an account of chromosomal aberrations in cancer cells. Such abnormalities have typically been associated with hematologic cancers, but recent work has shown a variety of chromosomal changes in solid tumors, …
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… for hematologic malignancies results from the donor immunity to antigens expressed in leukemia cells in the recipient. Similar immune responses have now been identified in patients with renal cell cancer with tumor regression after …
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This agent has been shown to bind to thiols and increase intracellular oxidants, inducing apoptosis in hematologic cancer cells. Pancreatic cancers are known to be sensitive to oxidation, suggesting this disease may be an appropriate …
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Also interesting was a patent (#7408095) issued to the company Phylonix Pharmaceuticals covering the use of pre-immune zebrafish as an alternative immune deficient host for studying human cells, particularly cancer. …
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Costa rica at Fox Chase Cancer Center have developed a new technique to speed discovery of drug targets in chemical genetics. G is increased, and the stability of the system itself is increased. The dried bacteria concentrate may …
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Blocking mTOR creates a starvation-like effect in cancer cells by interfering with cell growth, division, metabolism, and angiogenesis. Multiple Phase 1 and 2 clinical trials of deforolimus in solid tumors and hematologic cancers have …
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